5-Chloro-1-(4-chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carbaldehyde CAS 1152976-53-8
| CAS No. | 1152976-53-8 |
| Molecular Formula | C11H5Cl2F3N2O |
| Molecular Weight | 309.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-1-(4-chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carbaldehyde (CAS 1152976-53-8), molecular formula C11H5Cl2F3N2O and molecular weight 309.07 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-1-(4-chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carbaldehyde (C11H5Cl2F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-1-(4-chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H5Cl2F3N2O |
| Molecular Weight | 309.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-1-(3-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 1152576-85-6)
- 2-(2-Chloro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride (CAS 511533-50-9)
- 5-Chloro-2-(2,2,2-trifluoroethoxy)benzene-1-sulfonyl chloride (CAS 111762-22-2)
- 5-Chloro-2-methyl-4-(trifluoromethoxy)benzenesulfonyl chloride (CAS 1706447-06-4)
- 927800-47-3 4-Chloro-6-fluoro-2-(trichloromethyl)quinoline DTXSID60588859 (CAS 927800-47-3)
- 6-Chloro-3-((2-chloro-3-fluoropyridin-4-yl)methylene)indolin-2-one (CAS 1398569-88-4)
- 6-Chloro-3-methyl-5-(2,2,2-trichloroethyl)isoquinoline (CAS 919994-52-8)
- 2-Chloro-n'-(2-chlorobenzoyl)benzohydrazide (CAS 38192-13-1)
Recommended Standards
- N2-[4-(trifluoromethyl)phenyl]-4,6-dichloro-1,3,5-triazin-2-amine (CAS 169323-78-8)
- Ethyl 6-bromo-2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate (CAS 2451905-07-8)
- 1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride (CAS 175137-19-6)
- 5-(2-Bromo-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 2236573-61-6)
- 2,3-dihydro-1-benzofuran-2-carbohydrazide (CAS 176179-03-6)
- 5-(4-Nitrophenyl)-4,5-dihydroisoxazol-5-ol (CAS 53009-38-4)
- 2-(4-Bromophenyl)-5,8-dioxaspiro-[3.4]octane-2-carboxylic acid (CAS 1199586-87-2)
- Tigecycline-d9 (CAS 2699607-86-6)
- 3-((o-Tolylamino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione (CAS 370848-29-6)
- 2-(1H-1,2,4-Triazol-5-yl)aniline (CAS 6219-58-5)
- 2-Chloro-5-(2-mercapto-4,4-dimethylpyrimidin-1(4H)-yl)benzoic acid (CAS 1142213-01-1)
- 1,3-Dimethylpyrazole (CAS 694-48-4)
- Stearoyl-L-cysteine (CAS 67603-50-3)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
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