3-Chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile CAS 1155846-86-8
| CAS No. | 1155846-86-8 |
| Molecular Formula | C13H6ClF3N2O2 |
| Molecular Weight | 314.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile (CAS 1155846-86-8) is a high-purity analytical reference standard with the molecular formula C13H6ClF3N2O2 and a molecular weight of 314.65 g/mol.
3-Chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile (C13H6ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-Chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H6ClF3N2O2 |
| Molecular Weight | 314.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-(1H-pyrazol-5-yl)isoxazole (CAS 1031703-74-8)
- 9-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-9H-purin-6-amine (CAS 1354448-73-9)
- 2-{3-[(2-chloro-6-fluorophenyl)methyl]-2,4,5-trioxoimidazolidin-1-yl}acetic acid (CAS 303986-53-0)
- 4-Chloro-1-(3-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 650628-51-6)
- 4-CHLORO-2-(4-FLUOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE (CAS 1420885-98-8)
- 2-(2-Chloro-4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine (CAS 372122-57-1)
- 8-Chloro-2-(4-fluorophenyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 353258-25-0)
- 2-((7-Chloro-4-nitrobenzo[c][1,2,5]oxadiazol-5-yl)amino)ethyl propionate (CAS 705952-09-6)
Recommended Standards
- Simethicone Impurity N3 (CAS 3081-07-0)
- 2-(4-(1H-1,2,4-triazol-5-yl)-1H-pyrazol-1-yl)-3-chloro-5-(trifluoromethyl)pyridine (CAS 321526-20-9)
- Palbociclib Impurity 171 (CAS CATO-C4X-1125171)
- Didecylsulfane (CAS 693-83-4)
- 2-(5-Methyl-2-thienyl)quinoline-4-carbonyl chloride (CAS 1160264-88-9)
- 6-bromo-2-methylpyrazolo[1,5-a]pyrimidine-3-sulfonamide (CAS 2031259-16-0)
- tert-Butyl 1-methyl-2-oxo-3-azepanylcarbamate (CAS 1424939-98-9)
- 2-Chloro-n-[2-(2-methylphenyl)ethyl]acetamide (CAS 141463-66-3)
- N-Cbz-4-iodoaniline (CAS 93298-14-7)
- 2-Cyano-N-(2,6-diethylphenyl)acetamide (CAS 380190-55-6)
- 1-(4-Methoxy-3-(trifluoromethyl)benzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1604036-72-7)
- 2-(3-Aminopyridin-4-yloxy)ethanol (CAS 1040316-57-1)
- IR-813 perchlorate (CAS 201024-57-9)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com