Nicorandil Impurity 5 CAS 1157-74-0
| CAS No. | 1157-74-0 |
| Molecular Formula | C10H12N4O7 |
| Molecular Weight | 300.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nicorandil Impurity 5 (CAS 1157-74-0, C10H12N4O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nicorandil Impurity 5 (C10H12N4O7) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicorandil Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12N4O7 |
| Molecular Weight | 300.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Nicorandil Standards
- Nicorandil impurity 59 (CAS CATO-C4X-190759)
- Nicorandil impurity 68 (CAS CATO-C4X-190768)
- Nicorandil Impurity 50 (CAS CATO-C4X-190750)
- Nicorandil Impurity 55 (CAS 3612-79-1)
- Nicorandil Impurity 28 (CAS 34104-46-6)
- Nicorandil Impurity 18 (CAS CATO-C4X-190718)
- Nicorandil impurity 62 (CAS CATO-C4X-190762)
- Nicorandil impurity 61 (CAS CATO-C4X-190761)
Recommended Standards
- 3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7,9-dihydro-1H-purine-2,6,8(3H)-trione (CAS 2124-54-1)
- 2-(2-((5-Formylfuran-2-yl)methoxy)-2-oxoethyl)-2-hydroxysuccinic acid (CAS 222973-44-6)
- Isodemethylwedelolactone (CAS 350681-33-3)
- Cinnabarinic Acid (CAS 606-59-7)
- Relugoli Impurity 142 (CAS CATO-C4X-2429142)
- Flunarizine impurity 57 (CAS 114374-24-2)
- Pranoprofen Impurity 27 (CAS CATO-C4X-181127)
- Atosiban Impurity 81 (CAS CATO-C4X-229381)
- 1-Bromo-4-chloro-3-(difluoromethyl)-2-fluorobenzene (CAS 943830-37-3)
- (3-Cyano-4,5-difluorophenyl)boronic acid (CAS 2199440-57-6)
- Azido-PEG23-amine (CAS 2172677-19-7)
- Methyl 2-bromo-4,4,4-trifluorobutanoate (CAS 1365988-14-2)
- (R)-1-(6-bromopyridin-3-yl)ethan-1-amine dihydrochloride (CAS 1257637-89-0)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
Why CATO?
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