Lesinurad Impurity 3 CAS 1158970-76-3
| CAS No. | 1158970-76-3 |
| Molecular Formula | C15H12BrN3S |
| Molecular Weight | 346.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Lesinurad Impurity 3 (CAS 1158970-76-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12BrN3S and a molecular weight of 346.24 g/mol.
The molecular framework of Lesinurad Impurity 3 (C15H12BrN3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12BrN3S |
| Molecular Weight | 346.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lesinurad Standards
- Lesinurad Impurity 2 (CAS 1384208-36-9)
- Lesinurad Impurity 32 (CAS 1158970-37-6)
- Lesinurad Impurity 9 (CAS 1533519-85-5)
- Lesinurad Impurity 6 (CAS CATO-C4X-14786)
- Lesinurad Impurity 1 (CAS 1533519-98-0)
- Lesinurad Impurity 12 (CAS CATO-C4X-147812)
- Lesinurad Impurity E (CAS 1210330-64-5)
- Lesinurad Impurity 14 (CAS 1533519-93-5)
Recommended Standards
- N-Benzyl-5-bromo-1-benzothiophene-2-carboxamide (CAS 439108-01-7)
- tert-Butyl 3-(2,6-dichlorophenyl)-3-hydroxy-1-piperidinecarboxylate (CAS 1353504-65-0)
- 5-(4-Bromophenyl)-N-(p-tolyl)-1,3,4-thiadiazol-2-amine (CAS 92433-18-6)
- 3,3-Bis(diethoxyphosphoryl)propanoic acid (CAS 151869-73-7)
- Dexamethasone Impurity 715 Disodium Salt (CAS 39005-10-2)
- Creatine Phosphate Impurity 5 (CAS 2304584-35-6)
- Hydralazine Impurity 4 (CAS CATO-C4X-16594)
- 4-D-Ser-Ganirelix (CAS CATO-C4X-23736)
- 2,4-Difluoro-6-methylbenzamide (CAS 1803812-71-6)
- 2-[(4-chlorophenyl)methyl]-2-methylpyrrolidine hydrochloride (CAS 1909327-53-2)
- Ethyl 4-(2,4-dioxo-1,3-diazaspiro[4.5]Decan-3-yl)benzoate (CAS 1352517-28-2)
- Cetirizine Impurity 34 (Mixture of Diastereomers) (CAS 1243652-36-9)
- 2-(Methylamino)pyrimidine-4-carbaldehyde hydrochloride (CAS 2249723-18-8)
- Compstatin control peptide (CAS 301544-78-5)
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