Lesinurad Impurity 1 CAS 1533519-98-0
| CAS No. | 1533519-98-0 |
| Molecular Formula | C17H14ClN3O2S |
| Molecular Weight | 359.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 359.83 g/mol gives Lesinurad Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Lesinurad Impurity 1 (CAS 1533519-98-0) is a certified pharmaceutical impurity reference standard with the molecular formula C17H14ClN3O2S and a molecular weight of 359.83 g/mol.
Structurally, Lesinurad Impurity 1 (C17H14ClN3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 359.83 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H14ClN3O2S |
| Molecular Weight | 359.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lesinurad Standards
- Lesinurad Impurity E (CAS 1210330-64-5)
- Lesinurad Impurity 6 (CAS CATO-C4X-14786)
- Lesinurad Impurity 3 (CAS 1158970-76-3)
- Lesinurad Impurity 11 (CAS CATO-C4X-147811)
- Lesinurad Impurity 8 (CAS 1158970-49-0)
- Lesinurad Impurity 2 (CAS 1384208-36-9)
- Lesinurad Impurity 32 (CAS 1158970-37-6)
- Lesinurad Impurity 9 (CAS 1533519-85-5)
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