Drospirenone EP Impurity C CAS 116298-21-6
| CAS No. | 116298-21-6 |
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Drospirenone EP Impurity C is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Drospirenone EP Impurity C (CAS 116298-21-6, C21H26O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Drospirenone EP Impurity C (C21H26O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
Related Drospirenone Standards
- Drospirenone Impurity N1 (CAS 82543-15-5)
- Drospirenone Impurity N4 (CAS 2963-69-1)
- Drospirenone Impurity N2 (CAS 82543-16-6)
- Drospirenone EP Impurity D (CAS 67372-69-4)
- Drospirenone Ether Impurity (CAS 90376-21-9)
- Drospirenone EP Impurity A (CAS 67372-68-3)
- Drospirenone Impurity 14 (CAS CATO-C4X-162414)
- Drospirenone (CAS 67392-87-4)
Recommended Standards
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- Exemestane Impurity 33 (CAS CATO-C4X-164133)
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