Drospirenone EP Impurity D CAS 67372-69-4
| CAS No. | 67372-69-4 |
| Molecular Formula | C23H28O3 |
| Molecular Weight | 352.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Drospirenone EP Impurity D.
Drospirenone EP Impurity D (CAS 67372-69-4) is a certified pharmaceutical impurity reference standard with the molecular formula C23H28O3 and a molecular weight of 352.47 g/mol.
Drospirenone EP Impurity D (C23H28O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H28O3 |
| Molecular Weight | 352.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
Related Drospirenone Standards
- Drospirenone Ether Impurity (CAS 90376-21-9)
- Drospirenone EP Impurity A (CAS 67372-68-3)
- Drospirenone Impurity 14 (CAS CATO-C4X-162414)
- Drospirenone (CAS 67392-87-4)
- Drospirenone EP Impurity E (CAS 90457-65-1)
- Drospirenone EP Impurity K (CAS 889652-31-7)
- Drospirenone EP Impurity F (CAS CATO-C4X-16245)
- Drospirenone EP Impurity I (CAS 2896199-04-3)
Recommended Standards
- (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dien-1-oic acid 15-Keto-PGF2a 15-Keto-PGF2alpha 15-Keto-prostaglandin F2a 15-Keto-prostaglandin F2alpha 15-Ketoprostaglandin F2alpha 15-oxoprostaglandin F2alpha 35850-13-6 CHEBI:28442 (CAS 35850-13-6)
- Oseltamivir Impurity 195 (CAS 312904-18-0)
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