3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid CAS 1163729-49-4
| CAS No. | 1163729-49-4 |
| Molecular Formula | C6H7F3O3 |
| Molecular Weight | 184.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid.
3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid (CAS 1163729-49-4), molecular formula C6H7F3O3 and molecular weight 184.11 g/mol, is a CATO reference standard with documented purity and traceability.
3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid (C6H7F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H7F3O3 |
| Molecular Weight | 184.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Hydroxy Standards
- 6-Hydroxy-4-nitropicolinic acid (CAS 1393572-16-1)
- 6-Hydroxy-5-nitropicolinic acid (CAS 1595036-59-1)
- cis-3-hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid (CAS 1690177-86-6)
- (R)-4-hydroxy-4-(trifluoromethyl)tetrahydro-2H-pyran-2-one (CAS 956398-59-7)
- (s)-4-Hydroxy-4-(trifluoromethyl)tetrahydro-2h-pyran-2-one (CAS 956398-58-6)
- 3-Hydroxy-3-(trifluoromethyl)tetrahydro-4H-pyran-4-one (CAS 693245-82-8)
- 4-Hydroxy-4-(trifluoromethyl)tetrahydro-2H-pyran-2-one (CAS 83191-83-7)
- 4-Hydroxy-5-nitronicotinic acid (CAS 911461-03-5)
Recommended Standards
- 2-Hydroxypyrimidine-4,6-dicarboxylic acid (CAS 114832-74-5)
- 2-(Trifluoromethyl)tetrahydrofuran-3-carboxylic acid (CAS 1248551-27-0)
- 4-Nitronicotinic acid N-oxide (CAS 1078-05-3)
- 4-(2,2,2-trifluoroethoxy)but-2-enoic acid (CAS 1251452-36-4)
- 8-Chloro-4-iodoisoquinolin-3-amine (CAS 2234239-94-0)
- Fmoc-5-amino-2,4-dimethoxy-benzoic acid (CAS 1076196-98-9)
- 5-(Methylthio)-3,7-dioxo-9-phenyl-8-oxa-2,4,6-triazanon-4-enoicAcidPhenylmethylEster (CAS 176106-49-3)
- Vitamin K1 Impurity 41 (CAS 1778736-16-5)
- 6-Fluoropyrido[3,4-d]pyrimidin-4(3H)-one, 97% (CAS 171178-44-2)
- Methyl 5-bromo-4-fluoro-2-methoxybenzoate (CAS 314298-22-1)
- 1,3-Dichloro-2-methyl-4-(trifluoromethyl)benzene (CAS 115571-64-7)
- 6-Bromo-3-methylpicolinonitrile (CAS 1379335-87-1)
- N-(2,2-Dimethylpropyl)aniline hydrochloride (CAS 75351-09-6)
- Biotinyl-Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 1816258-36-2)
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