Hydrocortisone Impurity 70 CAS 116816-20-7
| CAS No. | 116816-20-7 |
| Molecular Formula | C23H34ClNO2Si |
| Molecular Weight | 420.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Hydrocortisone Impurity 70 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Hydrocortisone Impurity 70 (CAS 116816-20-7, C23H34ClNO2Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Hydrocortisone Impurity 70 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 420.06 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H34ClNO2Si |
| Molecular Weight | 420.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydrocortisone Standards
- Hydrocortisone 17-Propionate (CAS 65980-97-4)
- Hydrocortisone 21-Propionate (CAS 6677-98-1)
- Hydrocortisone Impurity 36 (CAS 116846-74-3)
- Hydrocortisone Impurity 69 (CAS 2905373-61-5)
- Hydrocortisone Impurity 28 (CAS CATO-C4X-140128)
- Hydrocortisone Impurity 43 (CAS 7780-63-4)
- Hydrocortisone Impurity 24 (CAS CATO-C4X-140124)
- Hydrocortisone 21-Butyrate (CAS 6677-99-2)
Recommended Standards
- Perfluoro-4-methyl-3,6-dioxaoctane (CAS 95842-03-8)
- ((1,2-Diphenylethene-1,2-diyl)bis(4,1-phenylene))diboronicacid (CAS 1054451-31-8)
- 3H-Indol-3-one, 5-bromo-2-(5-bromo-1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro- (CAS 84-40-2)
- (E)-((1,2-Diphenylethene-1,2-diyl)bis(4,1-phenylene))diboronic acid (CAS 1239512-91-4)
- Allopurinol Impurity 32 (CAS 52632-17-4)
- Flurbiprofen Impurity 63 (CAS CATO-C4X-144463)
- Ibuprofen EP Impurity J (CAS CATO-C4X-1082148)
- 4-Acetamidocyclohexane-1-carboxylic acid (CAS 90942-88-4)
- H-p-Chloro-Phe-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 (Disulfide bond) (CAS 209006-18-8)
- Benzoylecgonine tetrahydrate (CAS 5928-96-1)
- 4-Chloro-1-isopropyl-1H-pyrazole (CAS 1205921-77-2)
- (1R,2R)-2-(2,5-dimethyl-1H-pyrrol-1-yl)cyclohexan-1-amine (CAS 764650-90-0)
- 6-(tert-Butyldimethylsiloxy)hexylmagnesium bromide, 0.50 M in THF (CAS 267898-36-2)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com