Hydrocortisone Impurity 36 CAS 116846-74-3
| CAS No. | 116846-74-3 |
| Molecular Formula | C23H32ClNO2Si |
| Molecular Weight | 418.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Hydrocortisone Impurity 36 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Hydrocortisone Impurity 36 (CAS 116846-74-3, C23H32ClNO2Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H32ClNO2Si, Hydrocortisone Impurity 36 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 418.04 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H32ClNO2Si |
| Molecular Weight | 418.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydrocortisone Standards
- Hydrocortisone 17-Propionate (CAS 65980-97-4)
- Hydrocortisone 21-Propionate (CAS 6677-98-1)
- Hydrocortisone Impurity 69 (CAS 2905373-61-5)
- Hydrocortisone Impurity 70 (CAS 116816-20-7)
- Hydrocortisone Impurity 28 (CAS CATO-C4X-140128)
- Hydrocortisone Impurity 43 (CAS 7780-63-4)
- Hydrocortisone Impurity 24 (CAS CATO-C4X-140124)
- Hydrocortisone EP Impurity J (CAS 16463-74-4)
Recommended Standards
- 5,5,6,6,7,7,8,8,8-Nonafluoro-3-iodooctan-1-ol (CAS 109574-81-4)
- Perfluorooctanoic acid-13C4 (CAS 960315-48-4)
- N-(4-Bromophenyl)-2-hydroxy-5-iodobenzamide (CAS 2627-76-1)
- 2-Fluoro-4-iodo-6-(pyrrolidin-1-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1309980-57-1)
- Oseltamivir impurity 281 (CAS CATO-C4X-1720281)
- Loxoprofen impurity 125 (CAS CATO-C4X-1488125)
- Ranitidine Impurity N6 (CAS 1197-40-6)
- 5-(Aminomethylene)-3-methyl-2-thioxothiazolidin-4-one (CAS 73855-56-8)
- Methyl (2E)-3-(2-bromophenyl)prop-2-enoate (CAS 92991-89-4)
- (1-Ethyl-2-methanesulfonyl-1h-imidazol-5-yl)methanol (CAS 1221341-97-4)
- 2-[2-Fluoro-3-(trifluoromethyl)phenoxy]-isonicotinic acid (CAS 1160264-54-9)
- 5-Fluorobenzo[c][1,2,5]oxadiazole 1-oxide (CAS 36389-16-9)
- 6-Hydroxy-2-(3-methoxybenzylidene)benzofuran-3(2h)-one (CAS 210360-97-7)
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com