Levofloxacin EP Impurity C(Levofloxacin N-Oxide) CAS 117678-38-3
| CAS No. | 117678-38-3 |
| Molecular Formula | C18H20FN3O5 |
| Molecular Weight | 377.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levofloxacin EP Impurity C(Levofloxacin N-Oxide) (C18H20FN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Levofloxacin EP Impurity C(Levofloxacin N-Oxide) (CAS 117678-38-3) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20FN3O5 and a molecular weight of 377.37 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levofloxacin EP Impurity C(Levofloxacin N-Oxide) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20FN3O5 |
| Molecular Weight | 377.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- (R)-Levofloxacin N-Oxide (CAS 117678-37-2)
- Levofloxacin Impurity 92 (CAS CATO-C4X-137192)
- Levofloxacin Impurity 52 (CAS 1152314-62-9)
- Levofloxacin Impurity 88 (CAS CATO-C4X-137188)
- Levofloxacin Impurity 34 (CAS 108224-82-4)
- Levofloxacin Impurity 40 (CAS 106939-30-4)
- Levofloxacin Methyl Ester (CAS 862690-19-5)
- Levofloxacin impurity 78 (CAS 107359-24-0)
Recommended Standards
- Ofloxacin EP Impurity F(Levofloxacin Impurity 25) (CAS 104721-52-0)
- Relebactam Impurity 41 (CAS CATO-C4X-214441)
- Avibactam Impurity 114 (CAS CATO-C4X-1348114)
- Relebactam Impurity 42 (CAS CATO-C4X-214442)
- Parecoxib Impurity 36 (CAS CATO-C4X-159136)
- N-Ethylcarbazole Impurity 4 (CAS 882883-55-8)
- Salbutamol Impurity 134 (CAS 115787-50-3)
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