Clarithromycin Impurity 20 CAS 118074-07-0
| CAS No. | 118074-07-0 |
| Molecular Formula | C38H69NO14 |
| Molecular Weight | 763.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clarithromycin Impurity 20.
As a process- or degradation-related impurity, Clarithromycin Impurity 20 (CAS 118074-07-0, C38H69NO14) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clarithromycin Impurity 20 (C38H69NO14) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clarithromycin Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C38H69NO14 |
| Molecular Weight | 763.95 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 1 |
Related Clarithromycin Standards
- Clarithromycin EP Impurity A (CAS 124412-58-4)
- Clarithromycin Impurity 19 (CAS CATO-C4X-100219)
- Clarithromycin 9-Oxime (CAS 103450-87-9)
- Clarithromycin EP Impurity C (CAS 127253-06-9)
- Clarithromycin EP Impurity L (CAS 127253-05-8)
- Clarithromycin EP Impurity E (CAS 81103-14-2)
- Clarithromycin EP Impurity F (CAS 128940-83-0)
- Clarithromycin EP Impurity P (CAS 123967-58-8)
Recommended Standards
- (14R)-Hydroxy Clarithromycin (CAS 116836-41-0)
- (Pyr6,Pro9)-Substance P (6-11) (CAS 79775-19-2)
- 5-oxo-l-prolyl-l-phenylalanyl-l-phenylalanyl-l-prolyl-l-leucyl-l-methioninamide 83929-84-4 AR-1G9331 (CAS 83929-84-4)
- N-Nitroso Azithromycin Impurity 46 (CAS CATO-C4X-100346)
- Lubiprostone Impurity 25 (CAS CATO-C4X-113625)
- CAS 388115-12-6 (CAS 388115-12-6)
- Tolvaptan Impurity 4 (CAS 1133419-00-7)
- (4-(Naphthalen-2-ylamino)phenyl)(phenyl)methanol (CAS 1063170-85-3)
- (4-Bromo-2-fluorophenyl)diethylphosphine oxide (CAS 2685825-05-0)
- 1104620-99-6 2-(2-Methyl-benzoimidazol-1-yl)-propionic acidhydrochloride 8723AC C11H13ClN2O2 (CAS 1104620-99-6)
- 1-(2-Chlorophenyl)-5-methyl-1h-pyrazole-3-carboxylic acid (CAS 1225601-14-8)
- (S)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)but-3-enoate (CAS 500872-35-5)
- HPA-12 (CAS 383418-30-2)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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