Folic Acid Impurity 45 CAS 1182291-60-6
| CAS No. | 1182291-60-6 |
| Molecular Formula | C7H7N5O3 |
| Molecular Weight | 209.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Folic Acid Impurity 45 (CAS 1182291-60-6, C7H7N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H7N5O3, Folic Acid Impurity 45 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 209.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7N5O3 |
| Molecular Weight | 209.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 5 |
Related Folic Standards
- Folic Acid EP Impurity F (CAS 1391194-56-1)
- Folic Acid Impurity 61 (CAS 99778-32-2)
- Folic Acid Impurity 25 (CAS 694514-39-1)
- Folic Acid Impurity 28 (CAS 712-29-8)
- Folic Acid Impurity 17 (CAS 712-30-1)
- Folic Acid Impurity 29 (CAS 708-75-8)
- Folic Acid Impurity 22 (CAS 921-03-9)
- Folic Acid Impurity 14 (CAS 4230-33-5)
Recommended Standards
- N-Nitroso Paraxanthine (CAS CATO-C4X-133010)
- Pentoxifylline Impurity 23 (CAS CATO-C4X-172823)
- Apremilast Impurity 71 (CAS CATO-C4X-100971)
- Theophylline Impurity 10 (CAS CATO-C4X-182310)
- Risedronate EP Impurity B Sodium Salt (CAS 105462-23-5（free base）)
- Tetrabenazine Impurity 57-d6 HCI (CAS CATO-C4X-274871)
- Amoxicillin impurity 105 (CAS CATO-C4X-1148105)
- Gt 949 (CAS 460330-27-2)
- 2,6-Diamino-5-hydroxypyrimidin-4(1H)-one (CAS 60337-65-7)
- Mycophenolate Impurity 26 (CAS CATO-C4X-151526)
- 2-Amino-5-[(3,4-dimethoxyphenyl)methyl]-5-phenyl-4,5-dihydro-1H-imidazol-4-one (CAS 512190-92-0)
- 1-(4-Chloro-2-methylphenyl)-2,2,2-trifluoroethan-1-ol (CAS 1695933-58-4)
- 2-bromoimidazo[2,1-b]thiazole-6-carboxylic acid (CAS 80354-00-3)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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