Folic Acid Impurity 22 CAS 921-03-9
| CAS No. | 921-03-9 |
| Molecular Formula | C3H3Cl3O |
| Molecular Weight | 161.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Folic Acid Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Folic Acid Impurity 22 (CAS 921-03-9, C3H3Cl3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Folic Acid Impurity 22 (C3H3Cl3O) contains a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 161.41 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C3H3Cl3O |
| Molecular Weight | 161.41 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Folic Standards
- Folic Acid Impurity 29 (CAS 708-75-8)
- Folic acid EP Impurity B (CAS 1004-75-7)
- Folic Acid Impurity 17 (CAS 712-30-1)
- Folic Acid Impurity 25 (CAS 694514-39-1)
- Folic Acid Impurity 28 (CAS 712-29-8)
- Folic Acid Impurity 61 (CAS 99778-32-2)
- Folic Acid Impurity 45 (CAS 1182291-60-6)
- Folic Acid EP Impurity F (CAS 1391194-56-1)
Recommended Standards
- Ibuprofen Impurity 105 (CAS 17880-86-3)
- Prilocaine Impurity 18 (CAS 26073-26-7)
- Trichloropropene Oxide (CAS 3083-23-6)
- 1,1,1-Trichloroacetone (CAS 918-00-3)
- Desmopressin EP Impurity B TFA salt (CAS CATO-C4X-22152)
- Ceftaroline Impurity 2 (CAS 700803-62-9)
- Docetaxel Impurity 89 (CAS CATO-C4X-161989)
- N-[(4-Chlorophenyl)methyl]-2-(3,5-dimethylphenoxy)-N-(2-methoxyethyl)acetamide (CAS 866043-10-9)
- 1-(4,6-Dimethylpyrimidin-2-yl)-6-(4-methoxyphenyl)-3-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 885457-06-7)
- 2-(1,3,2-Dioxaborolan-2-yl)benzonitrile (CAS 214360-79-9)
- 3-(tert-Butyl)-5-cyclopropoxy-N-methylisonicotinamide (CAS 1243361-42-3)
- 2-Amino-3-methylamino-5-(4’-methoxyphenyl)pyridine (CAS 1797979-39-5)
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- Exenatide Acetate (CAS 141732-76-5)
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