Triclabendazole EP Impurity D CAS 118353-04-1
| CAS No. | 118353-04-1 |
| Molecular Formula | C12H7Cl3N2O3 |
| Molecular Weight | 333.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Triclabendazole EP Impurity D (CAS 118353-04-1, C12H7Cl3N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H7Cl3N2O3, Triclabendazole EP Impurity D contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 333.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Triclabendazole EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7Cl3N2O3 |
| Molecular Weight | 333.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Triclabendazole Standards
- Triclabendazole EP Impurity B (CAS 68828-69-3)
- Triclabendazole (CAS 68786-66-3)
- Triclabendazole Impurity 3 (CAS 145770-88-3)
- Triclabendazole Impurity 4 (CAS 145770-89-4)
- Triclabendazole EP Impurity A (CAS 100648-13-3)
- Triclabendazole Impurity 5 (CAS 106791-37-1)
- Triclabendazole sulfoxide(Sodium) (CAS 2077198-33-3)
- Triclabendazole Impurity N1 (CAS CATO-CP116696)
Recommended Standards
- Pyrrolidine Linoleamide (CAS 3140-51-0)
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- p-Hexadecyloxyaniline (CAS 7502-06-9)
- 4-Chloro-1-(4-iodobenzyl)-1h-pyrazol-3-amine (CAS 1484509-81-0)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
- Lornoxicam impurity 93 (CAS CATO-C4X-201693)
- Roxadustat Impurity 138 (CAS CATO-C4X-2213138)
- N-ethyl-5-fluoro-2-hydroxy-N-isopropylbenzamide (CAS 1549490-65-4)
- 6-Chloro-2-nitropyridin-3-amine (CAS 146015-42-1)
- Ethyl 5-methyl-1-(o-tolyl)-1H-pyrazole-4-carboxylate (CAS 618092-36-7)
- 4-Amino-5-nitronicotinonitrile (CAS 1202780-80-0)
- 5-Fluoro-2-(2-(pyrrolidin-1-yl)ethoxy)benzaldehyde (CAS 1216116-47-0)
- 1-[4-(4-Chloro-6-methyl-pyrimidin-2-yl)-piperidin-1-yl]-2-methoxy-ethanone (CAS 1316220-59-3)
- C-Peptide（dog） (CAS 39016-05-2)
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