Berberine Impurity 15 Chloride CAS 1186107-72-1
| CAS No. | 1186107-72-1 |
| Molecular Formula | C18H16NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 345.78 g/mol gives Berberine Impurity 15 Chloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Berberine Impurity 15 Chloride (CAS 1186107-72-1, C18H16NO4Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H16NO4Cl, Berberine Impurity 15 Chloride contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 345.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Berberine Impurity 15 Chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16NO4 Cl |
| Molecular Weight | 345.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Berberine Impurity 29 (CAS 2375597-30-9)
- Berberine Impurity 3 (CAS 2435-73-6)
Recommended Standards
- Rosuvastatin Impurity 209 (CAS CATO-C4X-1169209)
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- (6-Chloropyridin-3-yl)(4-nitrophenyl)methanone (CAS 1187169-29-4)
- 3-(1H-Indol-2-yl)-N-methyl-1H-pyrazole-4-carboxamide (CAS 827318-48-9)
- 3-[(Benzyloxy)amino]-N-[(benzyloxy)carbonyl]-L-alanine (CAS 337368-14-6)
- 4-(1,3-Diethylimidazolidin-2-yl)-N-methylbenzamide (CAS 116368-57-1)
- 1-Ethyl-1H-pyrazole-3-sulfonamide (CAS 1699630-58-4)
- 1-(3-Amino-4-(benzyloxy)phenyl)ethanone (CAS 14347-15-0)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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