Berberine Impurity 16 Chloride CAS 2363741-22-2
| CAS No. | 2363741-22-2 |
| Molecular Formula | C18H16NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Berberine Impurity 16 Chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Berberine Impurity 16 Chloride (CAS 2363741-22-2, C18H16NO4Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H16NO4Cl, Berberine Impurity 16 Chloride contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 345.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H16NO4 Cl |
| Molecular Weight | 345.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 15 Chloride (CAS 1186107-72-1)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 29 (CAS 2375597-30-9)
- Berberine Impurity 3 (CAS 2435-73-6)
Recommended Standards
- Ibuprofen impurity 119 (CAS 15931-59-6)
- Valsartan Impurity 78 (CAS CATO-C4X-105778)
- Ivabradine Impurity 16 (CAS 73344-75-9)
- tert-Butyl 3-amino-2-(hydroxymethyl)piperidine-1-carboxylate (CAS 2089706-35-2)
- 2,4-Dimethyldecane (CAS 2801-84-5)
- Levodopa Impurity 25 (CAS CATO-C4X-167625)
- 5-Chloro-2-(hydroxymethyl)benzofuran (CAS 235082-69-6)
- Doxofylline Moxastine (CAS 21661-62-1)
- 3-(3-methylcyclohexyl)azetidine hydrochloride (CAS 2059935-41-8)
- D-Leu26-Tirzepatide (CAS CATO-CPTD788908)
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