Crisaborole Impurity 14 CAS 1187188-60-8
| CAS No. | 1187188-60-8 |
| Molecular Formula | C14H13BO4 |
| Molecular Weight | 256.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 14 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 14 (CAS 1187188-60-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H13BO4 and a molecular weight of 256.06 g/mol.
Crisaborole Impurity 14 (C14H13BO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole Impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H13BO4 |
| Molecular Weight | 256.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
Related Crisaborole Standards
- Crisaborole Impurity 35 (CAS CATO-C4X-202135)
- Crisaborole-d4 (CAS CATO-C4X-202134)
- Crisaborole Impurity 62 (CAS CATO-C4X-202162)
- Crisaborole Hydrate Salt (CAS 2760304-92-3)
- Crisaborole Impurity 10 (CAS 906673-42-5)
- Crisaborole Impurity 11 (CAS 943311-54-4)
- Crisaborole impurity 115 (CAS CATO-C4X-2021115)
- Crisaborole (CAS 906673-24-3)
Recommended Standards
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- 2-(((3-Chlorobenzyl)amino)methyl)-6-ethoxyphenol (CAS 1232780-48-1)
- 5,6-Dihydro-4H-cyclopenta[b]thiophen-4-amine (CAS 108046-24-8)
- 6-(2-Cyanopropan-2-yl)picolinic acid (CAS 878744-16-2)
- Avibactam Impurity 68 (CAS CATO-C4X-134868)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com