3-(2-Chloro-4-fluorophenyl)-4-methyl-1h-pyrazol-5-amine CAS 1187767-10-7
| CAS No. | 1187767-10-7 |
| Molecular Formula | C10H9ClFN3 |
| Molecular Weight | 225.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(2-Chloro-4-fluorophenyl)-4-methyl-1h-pyrazol-5-amine (CAS 1187767-10-7) is a high-purity analytical reference standard with the molecular formula C10H9ClFN3 and a molecular weight of 225.65 g/mol.
The molecular framework of 3-(2-Chloro-4-fluorophenyl)-4-methyl-1h-pyrazol-5-amine (C10H9ClFN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 3-(2-Chloro-4-fluorophenyl)-4-methyl-1h-pyrazol-5-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClFN3 |
| Molecular Weight | 225.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 4-Chloro-1-(2-fluorobenzyl)-1,2-dihydro-3h-pyrazol-3-imine (CAS 1001757-51-2)
- 4-Chloro-1-[(4-fluorophenyl)methyl]-1h-pyrazol-3-amine (CAS 1001757-53-4)
- 4-Chloro-1-(3-fluorobenzyl)-1H-pyrazol-3-amine (CAS 1001757-55-6)
- 1-[(2-Chloro-4-fluorophenyl)methyl]-1H-pyrazol-4-amine (CAS 1002033-29-5)
- (R)-1-(2-Chloro-8-fluoroquinolin-3-yl)ethanol, 97% (CAS 1065481-27-7)
- (R)-1-(2-chloro-7-fluoroquinolin-3-yl)ethan-1-ol (CAS 1065483-17-1)
- 3-(4-Chloro-2-fluorophenyl)-4-methyl-1h-pyrazol-5-amine (CAS 1146218-11-2)
- 3-(5-Chloro-2-fluorophenyl)-1-methyl-1h-pyrazol-5-amine (CAS 1152666-84-6)
Recommended Standards
- 1-(2-Chloro-6-fluorobenzyl)-1h-imidazol-2-amine (CAS 1183840-76-7)
- 5-(Chloromethyl)-2-(2-fluorophenyl)-4-methyl-1,3-oxazole (CAS 1206978-61-1)
- N-((1H-pyrazol-3-yl)methyl)-4-chloro-3-fluoroaniline (CAS 1157625-61-0)
- 5-(Chloromethyl)-2-(4-fluorophenyl)-4-methyl-1,3-oxazole (CAS 1206979-05-6)
- Thiamethoxam Impurity 1 (CAS 131748-59-9)
- 2-(Difluoromethyl)-3-iodo-5-methylpyridine-4-carboxamide (CAS 1806859-53-9)
- 2-Ethyl-6-methyl-1,4-dihydroquinolin-4-one (CAS 123637-44-5)
- 1,4-dibenzyl-2-(fluoromethyl)piperazine (CAS 111760-36-2)
- 4-(Diethylcarbamoyl)benzene-1-sulfonyl chloride (CAS 923175-88-6)
- 2-(4-Chlorophenyl)-N-(4-ethoxyphenyl)quinoline-4-carboxamide (CAS 332156-93-1)
- 6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine (CAS 26232-35-9)
- Methyl 4-amino-1-ethyl-3-methyl-1h-pyrazole-5-carboxylate (CAS 210163-95-4)
- 3,5-Bis(2,2,2-trifluoroethoxy)aniline (CAS 438530-76-8)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
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