N-Desmethyl Loperamide-d3 CAS 1189488-17-2
| CAS No. | 1189488-17-2 |
| Molecular Formula | - |
| Molecular Weight | 466.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-Desmethyl Loperamide-d3 (C28H28D3ClN2O2) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
N-Desmethyl Loperamide-d3 (CAS 1189488-17-2) is a high-purity analytical reference standard with the molecular formula C28H28D3ClN2O2 and a molecular weight of 466.03 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H28D3ClN2O2 |
| Molecular Weight | 466.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 2-[5-(ethoxymethyl)-4-imino-2-methyl-pyrimidin-1-yl]-1-(4-phenylphenyl)ethanone (CAS 339287-20-6)
- 8-Fluoro-6-methoxyquinoline-3-carbonitrile (CAS 1823364-60-8)
- Ethyl 2-(5-methyl-2-propoxyphenyl)-2-oxoacetate (CAS 1369248-96-3)
- Cilastatin Impurity 44 (CAS CATO-C4X-196044)
- Nicardipine Impurity 8 (CAS 2469735-68-8)
- 4-Hydroxy-2-methylthieno[2,3-d]pyrimidine-5-carboxylic acid (CAS 1216288-05-9)
- 2-(4-Chloro-1H-pyrazol-1-yl)-N-(4-cyanophenyl)acetamide (CAS 1178331-17-3)
- (E)-[(2-Chloro-1,3-thiazol-5-yl)methylidene][2-(3,4-dimethoxyphenyl)ethyl]amine (CAS 303987-43-1)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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