O-Desmethyl Vandetanib CAS 910298-60-1
| CAS No. | 910298-60-1 |
| Molecular Formula | C21H22BrFN4O2 |
| Molecular Weight | 461.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including O-Desmethyl Vandetanib.
CATO supplies O-Desmethyl Vandetanib (CAS 910298-60-1), a certified reference material (molecular formula C21H22BrFN4O2, MW 461.33 g/mol) for analytical method development and quality control.
Structurally, O-Desmethyl Vandetanib (C21H22BrFN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 461.33 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), O-Desmethyl Vandetanib meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22BrFN4O2 |
| Molecular Weight | 461.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related O Standards
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Recommended Standards
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- N-(4-Iodophenyl)-2-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}acetamide (CAS 329778-78-1)
- 4-Bromo-N-(4-nitrobenzyl)-N-(p-tolyl)benzenesulfonamide (CAS 332156-42-0)
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- 6-Methyl-2-(pyridin-2-yl)quinoline-4-carbonyl chloride (CAS 1203090-75-8)
- 5,5'-(3-Methylpyridine-2,5-diyl)diisophthalic acid (CAS 2426561-00-2)
- 1,4-Dibromo-2,3,5,6-tetramethylbenzene (CAS 1646-54-4)
- 2-Methylnaphth[2,1-d]oxazole (CAS 20686-65-1)
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