Meclozine EP Impurity B CAS 119-56-2
| CAS No. | 119-56-2 |
| Molecular Formula | C13H11ClO |
| Molecular Weight | 218.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Meclozine EP Impurity B (CAS 119-56-2, C13H11ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Meclozine EP Impurity B (C13H11ClO) contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 218.68 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Meclozine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClO |
| Molecular Weight | 218.68 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Meclozine Standards
Recommended Standards
- Permethrin EP Impurity E (CAS 53874-66-1)
- Bedaquiline Impurity 67 (CAS 345949-37-3)
- N-benzyl-6-chloropyridin-2-amine (CAS 29449-76-1)
- Cloperastine Impurity 3 (CAS 6954-45-6)
- Sulbactam Impurity 15 (CAS 123285-25-6)
- Clopidogrel Impurity 58 (CAS CATO-C4X-102958)
- Sacubitril Impurity 24 (CAS 2459446-52-5)
- trans-4-(2-(2-Fluorophenyl)-2-oxoethyl)cyclohexanecarboxylic acid (CAS 736136-58-6)
- (4-(Difluoromethyl)-2-fluoro-5-methoxypyridin-3-yl)methanol (CAS 1804467-90-0)
- tert-Butyl 5-bromo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate (CAS 2314394-64-2)
- 1,1,1,3,8,9-Hexachlorononane (CAS 865306-21-4)
- N-(5-Bromo-2-methoxyphenyl)-1,3-propanesultam (CAS 1250914-47-6)
- 2-chloro-3-methyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one (CAS 1823921-16-9)
- Cyclolinopeptide B (CAS 193139-41-2)
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