Raltegravir EP Impurity E CAS 1193687-87-4
| CAS No. | 1193687-87-4 |
| Molecular Formula | C20H22N6O5 |
| Molecular Weight | 426.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Raltegravir EP Impurity E (CAS 1193687-87-4, C20H22N6O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H22N6O5, Raltegravir EP Impurity E contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 426.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Raltegravir EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22N6O5 |
| Molecular Weight | 426.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 6 |
Related Raltegravir Standards
- Raltegravir Diketo Ethoxy Impurity (CAS 1193687-88-5)
- Raltegravir (CAS 518048-05-0)
- Raltegravir 5-Methoxy Impurity (CAS CATO-C4X-26158)
- Raltegravir EP Impurity D (CAS 1064706-98-4)
- Raltegravir -D6 (CAS 1100750-98-8)
- Raltegravir Impurity15 (CAS 519028-33-2)
- Raltegravir EP Impurity C (CAS 1391918-17-4)
- Raltegravir EP Impurity B (CAS 1193687-85-2)
Recommended Standards
- Z-Ser(Bzl)-OSu (CAS 98647-23-5)
- N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-3-nitrobenzamide (CAS 1415560-17-6)
- Z-Gly-Pro-pNA (CAS 65022-15-3)
- N-(Furan-2-ylmethyl)-2-imino-5-oxo-1-(pyridin-3-ylmethyl)-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 371144-13-7)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Voriconazole Impurity 88 (CAS CATO-C4X-136688)
- Cholecalciferol Impurity 30 (CAS CATO-C4X-158630)
- 1-(4-Hydroxy-5-methoxypyridin-3-yl)ethan-1-one (CAS 1393544-77-8)
- (4-(Benzo[d]thiazol-2-yloxy)piperidin-1-yl)(pyrazin-2-yl)methanone (CAS 1251546-89-0)
- N-(2-(2-carbamothioylhydrazinyl)-2-oxoethyl)benzamide (CAS 83530-35-2)
- 2,5-Dimethyl-7,7,8,8-tetracyanoquinodimethane (CAS 1487-82-7)
- 2,2'-(Piperidine-4,4-diyl)bis(ethan-1-ol) (CAS 367282-75-5)
- Benzyl 8-hydroxyquinoline-2-carboxylate (CAS 1072830-83-1)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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