Brigatinib Impurity AP26123 CAS 1197958-75-0
| CAS No. | 1197958-75-0 |
| Molecular Formula | C28H37ClN7O2P |
| Molecular Weight | 570.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 570.07 g/mol gives Brigatinib Impurity AP26123 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Brigatinib Impurity AP26123 (CAS 1197958-75-0, C28H37ClN7O2P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Brigatinib Impurity AP26123 (C28H37ClN7O2P) contains a steroid core, an amide group, organophosphorus functionality, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.5, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 570.07 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H37ClN7O2P |
| Molecular Weight | 570.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Brigatinib Standards
Recommended Standards
- 41836-28-6 Tris N,N-bis(trimethylsilyl)amide yttrium (III), min. 98% (99.9%-Y) (REO) (CAS 41836-28-6)
- (((2R,3S,5R)-5-(6-Amino-2-bromo-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid (CAS 106867-29-2)
- Amlodipine Besilate EP Impurity B (CAS CATO-C4X-109562)
- 5-(4-Chlorophenyl)-4-{2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl}-2-{[(4-nitrophenyl)methyl]sulfanyl}pyrimidine (CAS 478248-96-3)
- Carbidopa EP Impurity B (CAS 18181-08-3)
- Noradrenaline Hydrochloride EP Impurity D (CAS CATO-C4X-151430)
- Darifenacin Impurity 5 (CAS CATO-C4X-16055)
- Alogliptin Impurity 44 (CAS 865758-95-8)
- 3-Chloro-8-fluoro-6-methoxyquinolin-4(1H)-one (CAS 724789-61-1)
- 1-(2-Chlorobenzyl)pyrrolidine-3-carbaldehyde (CAS 1447962-27-7)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(3-methylpiperidin-1-yl)furan-2-yl)boronate (CAS 2223009-58-1)
- (6-Ethoxypyridin-3-yl)methanamine (CAS 591771-82-3)
- 6-Chloro-1,2,3,4-tetrahydro-2,7-naphthyridine Hydrochloride (CAS 1335053-26-3)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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