5-Bromo-1,3-thiazole-2-carbonitrile CAS 1198154-99-2
| CAS No. | 1198154-99-2 |
| Molecular Formula | C4HBrN2S |
| Molecular Weight | 189.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Bromo-1,3-thiazole-2-carbonitrile (CAS 1198154-99-2), molecular formula C4HBrN2S and molecular weight 189.03 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Bromo-1,3-thiazole-2-carbonitrile (C4HBrN2S) is characterized by a nitrile group, sulfur-containing functionality, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4HBrN2S |
| Molecular Weight | 189.03 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 4-Bromo-2-cyanothiazole (CAS 1017781-52-0)
- 2-Bromo-4-cyanothiazole (CAS 848501-90-6)
- 2-Bromo-4-fluorotoluene (CAS 1422-53-3)
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- 1-Bromo-2-(fluoromethyl)benzene (CAS 446-47-9)
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Recommended Standards
- 5-Bromothiazole-4-carbonitrile (CAS 1257072-06-2)
- 2-Fluorobenzyl Bromide (CAS 446-48-0)
- 3-Bromoisothiazole-4-carbonitrile (CAS 1268247-73-9)
- Alogliptin Impurity 66 (CAS 452-63-1)
- (2-(Azetidin-1-ylmethyl)phenyl)(3,4-difluorophenyl)methanone (CAS 898755-33-4)
- 2,2,2-Trifluoro-1-(1-propyl-1H-pyrrol-3-yl)ethanone (CAS 74889-32-0)
- (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)boronic acid (CAS 499769-88-9)
- Etodolac EP Impurity E (CAS 57817-27-3)
- Bis-PEG17-acid (CAS 2226897-74-9)
- tert-butyl N-[2-hydroxy-1-(oxetan-3-yl)ethyl]carbamate (CAS 2306273-06-1)
- 1-(2-(5-Methyl-1H-indol-3-yl)ethyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 931374-78-6)
- (1S,3S)-3-Aminocyclohexane-1-carboxylic acid (CAS 933445-54-6)
- 4-Methyl-2-(3-methylcyclopentyl)pyrimidine-5-carboxylic acid (CAS 1482743-84-9)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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