Alogliptin Impurity 66 CAS 452-63-1
| CAS No. | 452-63-1 |
| Molecular Formula | C7H6BrF |
| Molecular Weight | 189.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Alogliptin Impurity 66.
As a process- or degradation-related impurity, Alogliptin Impurity 66 (CAS 452-63-1, C7H6BrF) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Alogliptin Impurity 66 (C7H6BrF) contains fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6BrF |
| Molecular Weight | 189.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
Related Alogliptin Standards
- Alogliptin Related Compound 87 (CAS 1246610-71-8)
- Alogliptin Related Compound 83 (CAS 130462-63-4)
- Alogliptin Impurity 37 (CAS 22115-41-9)
- Alogliptin Impurity 4 (CAS 172603-05-3)
- Alogliptin Impurity 35 (CAS CATO-C4X-109935)
- Alogliptin Impurity 38 (CAS 120977-94-8)
- Alogliptin Impurity 39 (CAS 6297-80-9)
- Alogliptin Impurity 41 (CAS 3177-80-8)
Recommended Standards
- 4-Fluorobenzyl bromide (CAS 459-46-1)
- 2-Fluorobenzyl Bromide (CAS 446-48-0)
- (2,6-dimethoxy-3-pyridinyl)boronic acid (2,6-dimethoxypyridin-3-yl)boronic acid 221006-70-8 A815922 (CAS 221006-70-8)
- 4-Bromo-2-cyanothiazole (CAS 1017781-52-0)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
- Docetaxel Impurity 10 (O-BOC N-pyruvy ldocetaxel) (CAS 1021489-55-3)
- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- Arecoline (CAS 63-75-2)
- 2,4-Dichloro-1-(methylsulfonyl)benzene (CAS 85901-48-0)
- 1-Amino-2-cyclopentylpropan-2-ol (CAS 1249360-64-2)
- Eltrombopag Impurity 56 (CAS CATO-C4X-119856)
- 3-Methoxypyrrolidine-1-sulfonamide (CAS 1427080-00-9)
- 4-Fluoro-3-methyl-2-nitrophenol (CAS 1806375-72-3)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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