Niraparib Impurity N9 CAS 1203683-54-8
| CAS No. | 1203683-54-8 |
| Molecular Formula | C16H22BrNO2 |
| Molecular Weight | 340.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Niraparib Impurity N9 (CAS 1203683-54-8), a pharmacopoeial impurity reference standard (molecular formula C16H22BrNO2, MW 340.26 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Niraparib Impurity N9 (C16H22BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22BrNO2 |
| Molecular Weight | 340.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Niraparib Standards
- Niraparib Impurity N3 (CAS 1203686-41-2)
- Niraparib Impurity N3 (CAS 2244064-26-2)
- Niraparib Impurity 52 (CAS CATO-C4X-232952)
- Niraparib impurity 25 (CAS CATO-C4X-232925)
- Niraparib Impurity 27 (CAS CATO-C4X-232927)
- Niraparib impurity 24 (CAS CATO-C4X-232924)
- Niraparib Impurity 30 (CAS CATO-C4X-232930)
- Niraparib-d5 (CAS 1038915-60-4 (non-labelled))
Recommended Standards
- tert-Butyl 8-bromo-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1203682-74-9)
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- 1-BOC-4-(2-BROMOPHENYL)PIPERIDINE (CAS 1198283-93-0)
- 1-Boc-7-bromo-4,4-dimethyl-3,4-dihydro-2H-quinoline (CAS 1187932-35-9)
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- [(4-methylimidazolidin-2-ylidene)amino]carbonitrile (CAS 49552-23-0)
- 3-[(4-methoxyphenyl)amino]propan-1-ol (CAS 69380-36-5)
- Cefepime Impurity 19 (CAS CATO-C4X-119319)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com