Niraparib Impurity N3 CAS 1203686-41-2
| CAS No. | 1203686-41-2 |
| Molecular Formula | C16H22BrNO2 |
| Molecular Weight | 340.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Niraparib Impurity N3.
Niraparib Impurity N3 (CAS 1203686-41-2) is a certified pharmaceutical impurity reference standard with the molecular formula C16H22BrNO2 and a molecular weight of 340.26 g/mol.
The molecular framework of Niraparib Impurity N3 (C16H22BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Niraparib Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H22BrNO2 |
| Molecular Weight | 340.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Niraparib Standards
- Niraparib Impurity N9 (CAS 1203683-54-8)
- Niraparib Impurity N3 (CAS 2244064-26-2)
- Niraparib Impurity 52 (CAS CATO-C4X-232952)
- Niraparib impurity 25 (CAS CATO-C4X-232925)
- Niraparib Impurity 27 (CAS CATO-C4X-232927)
- Niraparib impurity 24 (CAS CATO-C4X-232924)
- Niraparib Impurity 30 (CAS CATO-C4X-232930)
- Niraparib-d5 (CAS 1038915-60-4 (non-labelled))
Recommended Standards
- Tert-butyl 5-bromo-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1203684-82-5)
- Benzyl 3-(3-bromopropyl)piperidine-1-carboxylate (CAS 1208368-35-7)
- 1-[3,5-Bis(trifluoromethyl)benzoyl]-2-methylpiperazine (CAS 1240566-69-1)
- tert-Butyl 8-bromo-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1203682-74-9)
- Vortioxetine Impurity 15 (CAS 3070439-20-9)
- Tenofovir Impurity 77 (CAS 1643116-22-6)
- Oxacillin Impurity 43 (CAS CATO-C4X-232143)
- (2R,3S,4R,5R)-2-(6-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 20535-16-4)
- 1-(2-((4-Fluorobenzyl)thio)-4,5-dihydro-1H-imidazol-1-yl)-2-phenoxypropan-1-one (CAS 851800-13-0)
- Methotrexate Impurity 63 (CAS 2801801-56-7)
- 1,4-Bis(pentafluorothio)perfluorobenzene (CAS 1219501-60-6)
- 3-{2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}propanenitrile (CAS 19283-00-2)
- Cefpirome Impurity 30 (CAS CATO-C4X-120730)
- Liraglutide Impurity 26 (CAS CATO-C4X-199226)
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