Dapagliflozin Impurity 19 CAS 1204222-85-4
| CAS No. | 1204222-85-4 |
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 19 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Dapagliflozin Impurity 19 (CAS 1204222-85-4), a pharmacopoeial impurity reference standard (molecular formula C21H25ClO7, MW 424.87 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dapagliflozin Impurity 19 (C21H25ClO7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 109 (CAS 2088749-74-8)
- Dapagliflozin Impurity 110 (CAS CATO-C4X-1138110)
- Dapagliflozin Impurity 115 (CAS 1210040-47-3)
- Dapagliflozin Impurity 147 (CAS CATO-C4X-1138147)
- Dapagliflozin impurity 224 (CAS CATO-C4X-1138224)
- Dapagliflozin Impurity 7 (CAS 960404-86-8)
- Dapagliflozin Impurity 82 (CAS 461432-27-9)
- Dapagliflozin Impurity 37 (CAS 946525-39-9)
Recommended Standards
- Sotagliflozin Impurity 2 (CAS 1327165-94-5)
- 4-((4-Chlorophenyl)sulfonyl)-2-(2-fluorophenyl)-N-(3-methoxypropyl)oxazol-5-amine (CAS 823829-89-6)
- 1-(4-{4-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]piperidin-1-yl}-3-nitrophenyl)ethan-1-one (CAS 1030856-24-6)
- 2-(1-(5-(Allylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)ethyl)-3-chloro-5-(trifluoromethyl)pyridine (CAS 339010-61-6)
- Azacitidine Impurity 14 (CAS CATO-C4X-138814)
- Propofol Impurity 18 (CAS CATO-C4X-147318)
- Moxifloxacin Impurity 64 (CAS 18184-75-3)
- Isopropyl 4-amino-1-ethyl-1h-pyrazole-3-carboxylate (CAS 956234-31-4)
- 4-((6-Bromo-2-chloropyridin-3-yl)oxy)butanoic acid (CAS 62805-21-4)
- 2-(4-Methyl-2,5-dihydrothiazol-5-yl)ethanol (CAS 84041-80-5)
- 2-Bromo-N-(2-methoxyethyl)butanamide (CAS 1119452-33-3)
- Polymyxin B1-I TFA Salt (CAS 811435-10-6（free base）)
- ((2S,5R)-5-(6-Amino-9H-purin-9-yl)-2,5-dihydrofuran-2-yl)methyl acetate (CAS 62805-50-9)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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