Dapagliflozin Impurity 115 CAS 1210040-47-3
| CAS No. | 1210040-47-3 |
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 115 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dapagliflozin Impurity 115 (CAS 1210040-47-3, C21H25ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dapagliflozin Impurity 115 (C21H25ClO7) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 115 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 109 (CAS 2088749-74-8)
- Dapagliflozin Impurity 110 (CAS CATO-C4X-1138110)
- Dapagliflozin Impurity 147 (CAS CATO-C4X-1138147)
- Dapagliflozin Impurity 19 (CAS 1204222-85-4)
- Dapagliflozin impurity 224 (CAS CATO-C4X-1138224)
- Dapagliflozin Impurity 7 (CAS 960404-86-8)
- Dapagliflozin Impurity 82 (CAS 461432-27-9)
- Dapagliflozin Impurity 37 (CAS 946525-39-9)
Recommended Standards
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- Tofacitinib Impurity 152 (CAS CATO-C4X-1079152)
- 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrobenzoyl}morpholine (CAS 339276-57-2)
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- Epalrestat Impurity 24 (CAS CATO-C4X-223624)
- Flumazenil Impurity 15 (CAS CATO-C4X-143215)
- 1,1,1-[[(2-Bromoethyl)thio]methylidyne]trisbenzene (CAS 157522-54-8)
- DED4973C69 5187-23-5 5-Ethyl-1,3-dioxane-5-methanol 1,3-Dioxane-5-methanol, 5-ethyl- EINECS 225-967-8 UNII-DED4973C69 EC 225-967-8 (CAS 5187-23-5)
- 4-Amino-5-chloro-2,3-difluorobenzoic acid (CAS 2649788-84-9)
- 1-Bromobutane-4,4,4-d3 (CAS 55724-42-0)
- Ilaprazole Impurity 29 (CAS CATO-C4X-113029)
- 1-((3-Aminocyclobutyl)methyl)-3-butylurea (CAS 1462401-76-8)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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