6-beta-Exemestane EP Impurity B CAS 121021-51-0
| CAS No. | 121021-51-0 |
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-beta-Exemestane EP Impurity B (CAS 121021-51-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H26O3 and a molecular weight of 314.42 g/mol.
The molecular framework of 6-beta-Exemestane EP Impurity B (C20H26O3) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
Related beta Standards
- Exemestane EP Impurity B (CAS 184972-09-6)
- Exemestane Impurity 23 (CAS CATO-C4X-164123)
- Exemestane Impurity 6 (CAS 159354-61-7)
- Exemestane Impurity 33 (CAS CATO-C4X-164133)
- Exemestane Impurity 27 (CAS 600178-04-9)
- Exemestane Impurity 28 (CAS CATO-C4X-164128)
- Exemestane EP Impurity C (CAS 2130745-60-5)
- Exemestane Impurity 29 (CAS 49644-02-2)
Recommended Standards
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