Estradiol Impurity 25 CAS 4245-41-4
| CAS No. | 4245-41-4 |
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Estradiol Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Estradiol Impurity 25 (CAS 4245-41-4, C20H26O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Estradiol Impurity 25 (C20H26O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 314.42 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Estradiol Standards
- Estradiol Impurity 54 (CAS 1743-60-8)
- Estradiol Impurity 52 (CAS CATO-C4X-163652)
- Estradiol Impurity N3 (CAS 4954-14-7)
- Estradiol Impurity 20 (CAS 2398-63-2)
- Estradiol Impurity 58 (CAS CATO-C4X-163658)
- Estradiol Impurity N2 (CAS 92817-10-2)
- Estradiol Impurity 10 (CAS 1229-24-9)
- Estradiol Impurity 11 (CAS 3583-03-7)
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