Roflumilast Impurity 11 CAS 159783-78-5
| CAS No. | 159783-78-5 |
| Molecular Formula | C5H4BrClN2 |
| Molecular Weight | 207.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roflumilast Impurity 11.
As a process- or degradation-related impurity, Roflumilast Impurity 11 (CAS 159783-78-5, C5H4BrClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C5H4BrClN2, Roflumilast Impurity 11 contains a nitrile group, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 207.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4BrClN2 |
| Molecular Weight | 207.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast impurity 25 (CAS 1243391-44-7)
- Roflumilast Impurity 13 (CAS 53173-70-9)
- Roflumilast impurity 19 (CAS 151103-08-1)
- Roflumilast Impurity 17 (CAS 91872-02-5)
- Roflumilast Impurity 10 (CAS 127842-54-0)
- Roflumilast impurity 17 (CAS 151103-09-2)
- Roflumilast impurity 21 (CAS 162401-78-7)
- Roflumilast Impurity 41 (CAS 1882067-43-7)
Recommended Standards
- 5-Bromo-6-chloropyridin-2-amine (CAS 358672-65-8)
- 2-Bromoethanesulfonyl Chloride (CAS 54429-56-0)
- 5-Bromo-4-chloro-6-methylpyrimidine (CAS 3438-55-9)
- 1,3,5-Trichloro-2-vinylbenzene (CAS 15270-64-1)
- Dienogest EP Impurity L (CAS 5571-36-8)
- Bimatoprost Impurity 23 (CAS CATO-C4X-196423)
- Sodium Cromoglicate Impurity 13 (CAS 53878-47-0)
- 3-(2-Bromoacetyl)thiophene-2-sulfonamide (CAS 154127-28-3)
- 6-Amino-1-ethyl-1,2,3,4-tetrahydroquinolin-2-one (CAS 233775-33-2)
- 339527-86-5 TR11HQD73G Dipotassium tetracyanonickelate hydrate UNII-TR11HQD73G Nickelate(2-), tetrakis(cyano-kappac)-, dipotassium, hydrate, (sp-4-1)- Potassium tetracyanonickelate(ii) hydrate Potassium tetracyanonickelate(ii) hydrate [MI] (CAS 339527-86-5)
- Avacopan Impurity 6 (CAS 2763538-64-1)
- (4-(1H-pyrrol-1-yl)phenyl)(4-phenylpiperazin-1-yl)methanone (CAS 439097-45-7)
- (E)-[(6-Bromo-2H-1,3-benzodioxol-5-yl)methylidene][(2,4-dichlorophenyl)methoxy]amine (CAS 477846-76-7)
- Cycloaspeptide A (CAS 109171-13-3)
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