Nicardipine EP Impurity A HCl CAS 1216817-27-4
| CAS No. | 1216817-27-4 |
| Molecular Formula | C26H27N3O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nicardipine EP Impurity A HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Nicardipine EP Impurity A HCl (CAS 1216817-27-4), a pharmacopoeial impurity reference standard (molecular formula C26H27N3O6HCl, MW 513.98 g/mol) used for the identification and quantification of trace impurities in APIs.
Nicardipine EP Impurity A HCl (C26H27N3O6HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nicardipine EP Impurity A HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H27N3O6 HCl |
| Molecular Weight | 513.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nicardipine Standards
- Nicardipine Impurity N11 (CAS 101-06-4)
- Nicardipine Impurity 24 (CAS 102993-38-4)
- Nicardipine Impurity N1 (CAS 10323-98-5)
- Nicardipine Impurity 36 (CAS 115972-93-5)
- (S)-Nicardipine HCl (CAS 118934-78-4)
- Nicardipine O-Desmethyl (CAS 123973-71-7)
- Nicardipine Impurity 32 (CAS 134957-01-0)
- Nicardipine-d3 Hydrochloride (CAS 1432061-50-1)
Recommended Standards
- N-Nitroso Ondansetron impurity N1 (CAS CATO-C4X-249315)
- Milbemycin Oxime EP Impurity F (CAS 86691-98-7)
- Saxagliptin Impurity 25 (CAS CATO-C4X-104925)
- 1-(2,6-dioxaspiro[4.5]decan-9-yl)-2,2-difluoro-propan-1-one (CAS 1876861-45-8)
- 1-Hydroxyguanidine (CAS 13115-21-4)
- 5-(1-MEthyl-1h-pyrazol-4-yl)-3-(piperidin-4-yl)-1h-pyrrolo[2,3-b]pyridine (CAS 1206969-38-1)
- N-Boc-DL-alaninol (CAS 147252-84-4)
- (2S,3R,4S,5S,6R)-2-(((2R,3S,4R,5R,6S)-6-(2-chloro-4-nitrophenoxy)-4,5-dihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (CAS 135743-28-1)
- 1,1'-(Oxybis(ethane-2,1-diyl))bis(1H-imidazole) (CAS 134443-67-7)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com