Nicardipine Impurity 24 CAS 102993-38-4
| CAS No. | 102993-38-4 |
| Molecular Formula | C14H12N2O5 |
| Molecular Weight | 288.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 288.26 g/mol gives Nicardipine Impurity 24 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nicardipine Impurity 24 (CAS 102993-38-4, C14H12N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nicardipine Impurity 24 (C14H12N2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12N2O5 |
| Molecular Weight | 288.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 2 |
Related Nicardipine Standards
- Nicardipine Impurity 40 (CAS CATO-C4X-171040)
- Nicardipine Impurity 41 (CAS CATO-C4X-171041)
- Nicardipine Cyclohexenone Impurity (CAS 87625-92-1)
- Nicardipine Impurity 8 (CAS 2469735-68-8)
- Nicardipine Impurity 72 (CAS CATO-C4X-171072)
- Nicardipine Impurity 5 (CAS 2469555-30-2)
- Nicardipine Impurity 38 (CAS CATO-C4X-171038)
- Nicardipine Impurity 50 (CAS CATO-C4X-171050)
Recommended Standards
- Mesalazine EP Impurity S (CAS 1797983-23-3)
- Fluconazole Impurity 8 (CAS 163921-62-8)
- Fluconazole Impurity 10 (CAS 163921-61-7)
- N-nitroso Cyclen Impurity 130(Gadobutrol Impurity 130) (CAS CATO-C4X-2120130)
- Alectinib impurity 24 (CAS 1256585-32-6)
- Lapatinib Impurity 35 (CAS 1227853-06-6)
- Quetiapine Impurity 88 (CAS CATO-C4X-124488)
- (3-Bromo-2-methyl-phenyl)-carbamic acid tert-butyl ester (CAS 221538-03-0)
- 4-Fluoro-2,6-dimethylaniline (CAS 392-70-1)
- 5-(propan-2-yloxy)pyridine-3-sulfonamide (CAS 1547691-59-7)
- Methyl 2-(3,3-dimethyl-2-oxoazetidin-1-yl)benzoate (CAS 339100-88-8)
- tert-Butyl 6-benzyl-2,6-diazaspiro[3.5]nonane-2-carboxylate (CAS 1027333-16-9)
- Z-Dimethomorph (CAS 113210-98-3)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
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