Gemcitabine Impurity 37 CAS 122111-08-4
| CAS No. | 122111-08-4 |
| Molecular Formula | C12H10F2O5 |
| Molecular Weight | 272.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 272.20 g/mol gives Gemcitabine Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Gemcitabine Impurity 37 (CAS 122111-08-4, C12H10F2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Gemcitabine Impurity 37 (C12H10F2O5) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Gemcitabine Impurity 37 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H10F2O5 |
| Molecular Weight | 272.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Gemcitabine Standards
- Gemcitabine Impurity 24 (CAS 122111-07-3)
- Gemcitabine-13C-15N2 (CAS 1233921-74-8)
- Gemcitabine EP Impurity C-13C-15N2 (CAS 1233921-75-9)
- Gemcitabine Impurity 14 (CAS 294177-31-4)
- Gemcitabine Impurity 20 (CAS 153381-14-7)
- Gemcitabine EP Impurity C (CAS 114248-23-6)
- Gemcitabine Impurity N1 (CAS 103882-85-5)
- Gemcitabine (CAS 95058-81-4)
Recommended Standards
- Adenosine-13C5 (CAS 159496-13-6)
- N-(4-Bromophenyl)pentanethioamide (CAS 35274-23-8)
- Lactivicin (CAS 107167-31-7)
- Methyl 4-(4-(difluoromethoxy)phenyl)-2,4-dioxobutanoate (CAS 832738-26-8)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Clarithromycin Impurity 28 (CAS CATO-C4X-100228)
- Latanoprost Impurity 28 (CAS CATO-C4X-194128)
- N-(2-Methoxyethyl)-2-(4-methylphenoxy)-1-butanamine (CAS 1040686-90-5)
- 8-Ethyl-4-(naphthalene-1-carbonyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-47-5)
- N-Desbutyl-N-propyl Bumetanide-d5 (CAS 1346601-70-4)
- MR2034 (CAS 57236-85-8)
- 1-Benzyl-2-methylpiperidin-4-amine (CAS 321345-30-6)
- 6-Bromo-4-methoxy-1H-indole-3-carboxylic acid (CAS 1352394-11-6)
- Peptide Impurity 15 (CAS 1227750-69-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com