Clarithromycin Impurity 28 CAS CATO-C4X-100228
| CAS No. | CATO-C4X-100228 |
| Molecular Formula | C18H32ClN2O7PS |
| Molecular Weight | 486.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clarithromycin Impurity 28 (CAS CATO-C4X-100228, C18H32ClN2O7PS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H32ClN2O7PS, Clarithromycin Impurity 28 contains an amide group, a sulfone group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 486.95 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Clarithromycin Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H32ClN2O7PS |
| Molecular Weight | 486.95 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clarithromycin Standards
- Clarithromycin impurity 16(See C4X-100217) (CAS CATO-C4X-100216)
- Clarithromycin EP Impurity K (CAS 127157-35-1)
- Clarithromycin EP Impurity I (CAS 118058-74-5)
- Clarithromycin Impurity 35 (CAS CATO-C4X-100235)
- Clarithromycin EP Impurity N (CAS 144604-03-5)
- Clarithromycin EP Impurity B (CAS 299409-85-1)
- Clarithromycin EP Impurity D (CAS 101666-68-6)
- Clarithromycin impurity 14 (CAS 138109-92-9)
Recommended Standards
- Fenchlorphos Impurity 4 (CAS 56201-37-7)
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- 4,5-Dibromo-N-(3-iodophenyl)thiophene-2-carboxamide (CAS 749893-00-3)
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