Etodolac EP Impurity K CAS 122188-02-7
| CAS No. | 122188-02-7 |
| Molecular Formula | C18H23NO3 |
| Molecular Weight | 301.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Etodolac EP Impurity K (CAS 122188-02-7, C18H23NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Etodolac EP Impurity K is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 301.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23NO3 |
| Molecular Weight | 301.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Etodolac Standards
- Etodolac EP Impurity D (CAS 57917-63-2)
- Etodolac EP Impurity E (CAS 57817-27-3)
- Etodolac EP Impurity F (CAS 849630-65-5)
- Etodolac EP Impurity G (CAS 57816-83-8)
- 4-Oxo etodolac (CAS 111478-86-5)
- Etodolac Impurity 2 (CAS 101901-06-8)
- Etodolac Impurity 3 (CAS 101901-07-9)
- Etodolac Impurity 1 (CAS 101901-08-0)
Recommended Standards
- tert-Butyl (2R)-4,4-diethoxy-2-formylpiperidine-1-carboxylate (CAS 1212385-46-0)
- 2-Methoxy-6-(((4-propoxybenzyl)amino)methyl)phenol (CAS 1223887-93-1)
- tert-Butyl (2S)-4,4-diethoxy-2-formylpiperidine-1-carboxylate (CAS 1212152-15-2)
- tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (CAS 1229000-10-5)
- Elagolix Impurity 40 (CAS 830346-46-8)
- Epinephrine /Adrenaline Impurity 136 (CAS CATO-C4X-1849136)
- Midazolam Impurity 1 (CAS 59468-90-5)
- 2-Fluoro-3,4-dihydroxybenzaldehyde (CAS 61338-95-2)
- (2-Bromo-6-(difluoromethyl)-4-nitropyridin-3-yl)methanol (CAS 1805380-14-6)
- 4-((1-(tert-Butoxycarbonyl)piperidin-4-yl)oxy)-2-methoxybenzoic acid (CAS 162045-38-7)
- Rivastigmine Impurity 27 (CAS CATO-C4X-138427)
- 2-Chloro-3-fluorobenzeneboronic acid pinacol ester, 97% (CAS 1688698-58-9)
- (S)-1-(5-fluoropyrimidin-2-yl)ethan-1-amine (CAS 905587-29-3)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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