Neratinib Impurity 44 CAS 1222172-50-0
| CAS No. | 1222172-50-0 |
| Molecular Formula | C15H17N3O4 |
| Molecular Weight | 303.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Neratinib Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Neratinib Impurity 44 (CAS 1222172-50-0), a pharmacopoeial impurity reference standard (molecular formula C15H17N3O4, MW 303.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Neratinib Impurity 44 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 303.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H17N3O4 |
| Molecular Weight | 303.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 3 |
Related Neratinib Standards
- Neratinib Impurity 24 (CAS 848133-76-6)
- Neratinib Impurity 42 (CAS 1201080-23-0)
- Neratinib Impurity 40 (CAS 848133-75-5)
- Neratinib Impurity 27 (CAS CATO-C4X-113427)
- Neratinib Impurity 26 (CAS CATO-C4X-113426)
- Neratinib Impurity 56 (CAS CATO-C4X-113456)
- Neratinib Impurity 38 (CAS 2240142-43-0)
- Neratinib Impurity 43 (CAS 1222172-49-7)
Recommended Standards
- Apixaban Impurity 19 (CAS 503615-03-0)
- Ramosetron Impurity 11 (CAS 1352491-75-8)
- 2,2'-((2-(4-(carboxymethyl)piperazin-1-yl)ethyl)azanediyl)diacetic acid (CAS 136369-41-0)
- N-Nitroso Vilazodone Impurity 11 (CAS 2512217-82-0)
- Escitalopram EP impurity E (CAS CATO-C4X-110944)
- Hydroxychloroquine Impurity 68 (CAS 23443-05-2)
- Sofosbuvir Impurity 16 (CAS CATO-C4X-105216)
- Furo[3,4-c]pyridin-3(1H)-one (CAS 5657-52-3)
- 2-((4-Chloro-2-methylphenyl)amino)-5-nitrobenzonitrile (CAS 945367-47-5)
- (4-(Difluoromethyl)-2-iodo-6-methoxypyridin-3-yl)methanol (CAS 1806883-43-1)
- 1-(3,4-dimethoxyphenyl)-3-[3,5-di(trifluoromethyl)phenyl]prop-2-en-1-one (CAS 254096-57-6)
- (4Z)-2-[(4-Chlorophenyl)methoxy]-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (CAS 338419-54-8)
- 2,6-Dichloro-4-(hydroxymethyl)phenylboronic acid (CAS 2121514-53-0)
- D-Pro36-Tirzepatide (CAS CATO-CPTD788903)
Why CATO?
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