Neratinib Impurity 43 CAS 1222172-49-7
| CAS No. | 1222172-49-7 |
| Molecular Formula | C12H16N2O4 |
| Molecular Weight | 252.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Neratinib Impurity 43 (C12H16N2O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Neratinib Impurity 43 (CAS 1222172-49-7) is a certified pharmaceutical impurity reference standard with the molecular formula C12H16N2O4 and a molecular weight of 252.27 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Neratinib Impurity 43 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H16N2O4 |
| Molecular Weight | 252.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Neratinib Standards
- Neratinib Impurity 60 (CAS CATO-C4X-113460)
- Neratinib Impurity 52 (CAS CATO-C4X-113452)
- Neratinib Impurity 51 (CAS CATO-C4X-113451)
- Neratinib Impurity 25 (CAS 848133-87-9)
- Neratinib Impurity 38 (CAS 2240142-43-0)
- Neratinib Impurity 56 (CAS CATO-C4X-113456)
- Neratinib Impurity 26 (CAS CATO-C4X-113426)
- Neratinib Impurity 58 (CAS CATO-C4X-113458)
Recommended Standards
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- 1-methyl-1-(2,2,2-trifluoroethyl)hydrazine hydrochloride (CAS 2031258-63-4)
- 6-(5-Phenoxypyridin-3-yl)pyridazin-3(2H)-one (CAS 1333222-15-3)
- (S)-2-Amino-1-phenylethanol hydrochloride 71025-82-6 C8H12ClNO X3539 (CAS 71025-82-6)
- 2-Iodo-3-methoxynaphthalene (CAS 795278-91-0)
- 4-(3-Bromo-5-fluorophenyl)piperazin-1-ol (CAS 1704080-86-3)
- Peptide Impurity 26 (CAS 1350456-66-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com