Pazopanib Impurity 42 CAS 1226500-01-1
| CAS No. | 1226500-01-1 |
| Molecular Formula | C70H69N19O2S |
| Molecular Weight | 1240.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Pazopanib Impurity 42 (CAS 1226500-01-1, C70H69N19O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pazopanib Impurity 42 (C70H69N19O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C70H69N19O2S |
| Molecular Weight | 1240.49 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 46.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 19 |
| Sulfur Atoms | 1 |
Related Pazopanib Standards
- Pazopanib Impurity 41 (CAS 2095544-42-4)
- Pazopanib Impurity 49 (CAS CATO-C4X-172549)
- Pazopanib Impurity 31 (CAS CATO-C4X-172531)
- Pazopanib Impurity 14 (CAS CATO-C4X-172514)
- Pazopanib Impurity 39 (CAS 1252927-44-8)
- Pazopanib Impurity 37 (CAS 1226500-02-2)
- Pazopanib Impurity 50 (CAS 1226500-00-0)
- Pazopanib Impurity 52 (CAS CATO-C4X-172552)
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