3-Chloro-2-fluoropyridin-4-amine CAS 1227577-11-8
| CAS No. | 1227577-11-8 |
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-2-fluoropyridin-4-amine (CAS 1227577-11-8), molecular formula C5H4ClFN2 and molecular weight 146.55 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C5H4ClFN2, 3-Chloro-2-fluoropyridin-4-amine contains a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 146.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-fluoropyridin-3-amine (CAS 103999-78-6)
- 4-Chloro-6-(fluoromethyl)pyrimidine (CAS 1092289-36-5)
- 5-Chloro-2-fluoropyridin-4-amine (CAS 1227513-74-7)
- 3-Chloro-5-fluoropyridin-4-amine (CAS 1227581-38-5)
- 6-Chloro-2-fluoropyridin-3-amine (CAS 1227600-05-6)
- 3-chloro-6-fluoropyridin-2-amine (CAS 1232431-23-0)
- 5-Chloro-6-fluoropyridin-3-amine (CAS 1256790-26-7)
- 6-Chloro-5-fluoropyridin-2-amine (CAS 1256808-75-9)
Recommended Standards
- 2-Amino-3-chloro-5-fluoropyridine (CAS 1214330-79-6)
- Ceftezole Impurity 7 (CAS 41223-92-1)
- 5-Chloro-4H-1,2,4-triazole-3-carboxamide (CAS 54671-66-8)
- 4-Chloro-6-fluoropyridin-3-amine (CAS 1256808-96-4)
- 5-Bromo-3-(1H-pyrrol-1-yl)pyridin-2-amine (CAS 155630-03-8)
- Paeoniflorin sulfite (CAS CATO-C3D-263266)
- (3R,4R)-1-Benzyl-3,4-pyrrolidinediol (CAS 163439-82-5)
- Methyl 3-(thiophen-3-yl)propiolate (CAS 1340531-00-1)
- Isopropyl 2-amino-5-((2-methoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate (CAS 350997-03-4)
- Gold(1+), [μ-[1-(thio-κS:κS)-β-D-glucopyranose 2,3,4,6-tetraacetato]]bis(triethylphosphine)di-, chloride (CAS 74765-78-9)
- 1-(3,4-Dimethoxyphenethyl)-5-oxopyrrolidine-3-carbonitrile (CAS 1017458-04-6)
- (5-Fluoro-2-isopropoxypyridin-4-yl)boronic acid (CAS 1264127-92-5)
- 4-(4-Methoxyphenyl)-10-methyl-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5,9,11-pentaene (CAS 38956-32-0)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
Why CATO?
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