3-Chloro-5-fluoropyridin-4-amine CAS 1227581-38-5
| CAS No. | 1227581-38-5 |
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-5-fluoropyridin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-Chloro-5-fluoropyridin-4-amine (CAS 1227581-38-5), molecular formula C5H4ClFN2 and molecular weight 146.55 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, fluorine/chlorine substitution, 3-Chloro-5-fluoropyridin-4-amine is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 146.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-fluoropyridin-3-amine (CAS 103999-78-6)
- 4-Chloro-6-(fluoromethyl)pyrimidine (CAS 1092289-36-5)
- 5-Chloro-2-fluoropyridin-4-amine (CAS 1227513-74-7)
- 3-Chloro-2-fluoropyridin-4-amine (CAS 1227577-11-8)
- 6-Chloro-2-fluoropyridin-3-amine (CAS 1227600-05-6)
- 3-chloro-6-fluoropyridin-2-amine (CAS 1232431-23-0)
- 5-Chloro-6-fluoropyridin-3-amine (CAS 1256790-26-7)
- 6-Chloro-5-fluoropyridin-2-amine (CAS 1256808-75-9)
Recommended Standards
- 2-Amino-3-chloro-5-fluoropyridine (CAS 1214330-79-6)
- 4-Chloro-6-fluoropyridin-3-amine (CAS 1256808-96-4)
- Ceftezole Impurity 7 (CAS 41223-92-1)
- 5-Amino-2-chloro-4-fluoropyridine (CAS 1256811-74-1)
- 2-Amino-6-cyclopropylbenzonitrile (CAS 1093203-67-8)
- 3-Methoxy-4-phenoxyphenylboronic acid (CAS 1449001-29-9)
- 6-Chloro-2-fluoro-3-methylbenzenesulfonyl chloride (CAS 1706461-23-5)
- 1-[(2,6-dimethoxyphenoxy)methyl]-1h-pyrazole-3-carboxylic acid (CAS 1001519-23-8)
- (2E)-3-(4-tert-Butylphenyl)-1-(3,4-dichlorophenyl)prop-2-en-1-one (CAS 1354942-32-7)
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- (S)-5-(4-Bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole (CAS 1255936-24-3)
- 2-(6-Chloro-4-(difluoromethyl)-5-methylpyridin-2-yl)acetonitrile (CAS 1806938-88-4)
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