Levocetirizine Impurity 24 CAS 1232460-29-5
| CAS No. | 1232460-29-5 |
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Levocetirizine Impurity 24 (CAS 1232460-29-5, C21H25ClN2O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Levocetirizine Impurity 24 (C21H25ClN2O3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25ClN2O3 2*HCl |
| Molecular Weight | 425.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Levocetirizine Standards
- Levocetirizine Impurity 50 (CAS 1074-42-6)
- Levocetirizine Impurity 5 (CAS 109036-15-9)
- Levocetirizine Impurity 43 (CAS 1116338-10-3)
- Levocetirizine Impurity 45 (CAS 1150310-68-1)
- Levocetirizine Dihydrochloride - Impurity H (Hydrochloride Salt) (CAS 1177093-13-8)
- Levocetirizine Impurity 80 (CAS 1232460-31-9)
- Levocetirizine Impurity 17 (CAS 126517-38-2)
- Levocetirizine Impurity 35 (CAS 130018-76-7)
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