5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carbonitrile CAS 1240526-18-4
| CAS No. | 1240526-18-4 |
| Molecular Formula | C12H6ClF2N3 |
| Molecular Weight | 265.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carbonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carbonitrile (CAS 1240526-18-4), molecular formula C12H6ClF2N3 and molecular weight 265.65 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carbonitrile (C12H6ClF2N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-6-[(3,4-difluorophenyl)amino]pyridine-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H6ClF2N3 |
| Molecular Weight | 265.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 4-Chloro-5-methoxy-2-(3-nitrophenyl)pyrimidine (CAS 1147979-38-1)
- 5-(2-Chloro-5-nitrophenyl)-3-cyclopropyl-1,2,4-oxadiazole (CAS 1165931-67-8)
- 5-(5-Chloro-4-methyl-2-nitrophenyl)furan-2-carbaldehyde (CAS 1211027-21-2)
- 5-Chloro-4-(4-methyl-3-nitrophenyl)pyridazin-3(2h)-one (CAS 1245646-50-7)
- 2-(2-Chloro-6-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine (CAS 1378040-67-5)
- (4-Chloro-3-nitrophenyl)(1-methyl-1H-imidazol-2-yl)methanone (CAS 32902-22-0)
- 1-(5-(2-Chloro-4-nitrophenyl)furan-2-yl)ethan-1-one (CAS 657405-45-3)
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Recommended Standards
- 1-(4-Chlorophenyl)-2-(3-nitro-1h-pyrazol-1-yl)ethan-1-one (CAS 1240564-69-5)
- 1-(4-Chlorophenyl)-2-(4-nitro-1h-pyrazol-1-yl)ethan-1-one (CAS 1240579-38-7)
- 4-(Benzo[d][1,3]dioxol-5-yloxy)-6-chloropyrimidin-5-amine (CAS 1090892-67-3)
- 2-(2-Chloropyridin-3-yl)-5,6-difluoro-1H-benzo[d]imidazole (CAS 1281980-00-4)
- 8-Phenylnaphthalen-1-ol (CAS 129957-20-6)
- 6-β-Hydroxy Stanozolol (CAS 1206164-59-1)
- 4-(3-Ethoxy-2-methoxyphenyl)but-3-en-2-one (CAS 1286356-39-5)
- 1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)piperidin-4-amine (CAS 1525554-57-7)
- Mirogabalin Impurity 178 (CAS CATO-C4X-2924178)
- 5-Bromo-1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1255145-27-7)
- 5-(4-Chloro-3-nitrophenyl)-3-(2,5-dimethylphenyl)-1,2,4-oxadiazole (CAS 1707371-51-4)
- N-(4-Amino-2-methylphenyl)-2-(2,6-dimethylphenoxy)acetamide (CAS 953897-23-9)
- Flunarizine impurity 36 (CAS 57070-98-1)
- (10-31)Semaglutide (CAS CATO-C4X-2226283)
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