Atorvastatin Impurity 60 CAS 124401-38-3
| CAS No. | 124401-38-3 |
| Molecular Formula | C12H15NO2 |
| Molecular Weight | 205.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Atorvastatin Impurity 60 (CAS 124401-38-3, C12H15NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Atorvastatin Impurity 60 (C12H15NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H15NO2 |
| Molecular Weight | 205.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 1 |
Related Atorvastatin Standards
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Atorvastatin Impurity N2 (CAS 40281-50-3)
- Atorvastatin Impurity N3 (CAS 77294-82-7)
- Atorvastatin impurity 161 (CAS CATO-C4X-1132161)
- Atorvastatin Impurity 107 (CAS 125995-17-7)
- Atorvastatin Impurity 76 (CAS CATO-C4X-113276)
- Atorvastatin Impurity 135 (CAS 714963-28-7)
- Atorvastatin Impurity 53 (CAS 125988-01-4)
Recommended Standards
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- 4,6-dibromopyrazolo[1,5-a]pyridine-3-carbonitrile (CAS 2068065-63-2)
- Bilastine impurity 113 (CAS CATO-C4X-2253113)
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