Atorvastatin Impurity N2 CAS 40281-50-3
| CAS No. | 40281-50-3 |
| Molecular Formula | C14H11FO |
| Molecular Weight | 214.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Atorvastatin Impurity N2 (CAS 40281-50-3, C14H11FO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Atorvastatin Impurity N2 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 214.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H11FO |
| Molecular Weight | 214.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F-containing |
Related Atorvastatin Standards
- Atorvastatin Impurity N3 (CAS 77294-82-7)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Atorvastatin impurity 161 (CAS CATO-C4X-1132161)
- Atorvastatin Impurity 107 (CAS 125995-17-7)
- Atorvastatin Impurity 76 (CAS CATO-C4X-113276)
- Atorvastatin Impurity 60 (CAS 124401-38-3)
- Atorvastatin Impurity 135 (CAS 714963-28-7)
- Atorvastatin Impurity 53 (CAS 125988-01-4)
Recommended Standards
- 3-(Pyridin-3-yldiazenyl)pyridine-2,6-diamine (CAS 28365-08-4)
- 3'-Fluoro-4'-methyl-[1,1'-biphenyl]-3-carbaldehyde (CAS 885964-68-1)
- 3-(4-fluorophenyl)-3-methyloxolane-2,5-dione (CAS 98054-67-2)
- 3'-Fluoro-4'-methyl-[1,1'-biphenyl]-4-carbaldehyde (CAS 885964-50-1)
- Butylphthalide Impurity N5 (CAS 169141-21-3)
- Canagliflozin Impurity 75 (CAS CATO-C4X-112375)
- Atrasentan Impurity 31 (CAS 1059040-09-3)
- 55806-40-1 Daphnorin Daphnorine Daphnoretin-7-O-beta-D-glucoside (CAS 55806-40-1)
- 2-(trans-3-hydroxy-3-methylcyclobutyl)acetonitrile (CAS 2758915-47-6)
- 1-(2,6-Bis(3,5-bis(trifluoromethyl)phenyl)-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-7-nitro-1,2,3,4-tetrahydroquinoline (CAS 1818406-77-7)
- Oxybutynin Impurity 2 (CAS 31197-69-0)
- 3-(Difluoromethoxy)-5-(1H-pyrazol-4-yl)piperidine (CAS 2366183-17-5)
- 5,6,7,8-Tetrahydro-9H-cyclohepta[b]pyridin-9-one (CAS 41043-13-4)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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