Atorvastatin Impurity N3 CAS 77294-82-7
| CAS No. | 77294-82-7 |
| Molecular Formula | C14H11FO |
| Molecular Weight | 214.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Atorvastatin Impurity N3 (C14H11FO) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Atorvastatin Impurity N3 (CAS 77294-82-7, C14H11FO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11FO |
| Molecular Weight | 214.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related Atorvastatin Standards
- Atorvastatin Impurity N2 (CAS 40281-50-3)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Atorvastatin impurity 161 (CAS CATO-C4X-1132161)
- Atorvastatin Impurity 107 (CAS 125995-17-7)
- Atorvastatin Impurity 76 (CAS CATO-C4X-113276)
- Atorvastatin Impurity 60 (CAS 124401-38-3)
- Atorvastatin Impurity 135 (CAS 714963-28-7)
- Atorvastatin Impurity 53 (CAS 125988-01-4)
Recommended Standards
- 5-Amino-1-(4,6-dimethylpyrimidin-2-yl)-1H-pyrazole-4-carbonitrile (CAS 56898-44-3)
- 1-(4-Fluorophenyl)-2-phenylethanone (CAS 347-84-2)
- 4-Fluorophenylacetophenone, 97% (CAS 347-91-1)
- N,N-Diethyl-4,6-bis(hydroxyamino)-1,3,5-triazin-2-amine (CAS 33901-81-4)
- Lumateperone Impurity 35 Tosylate Salt (CAS CATO-C4X-220135)
- Hydroxychloroquine Impurity 69 DiHCl (CAS 860544-46-3 (free base))
- Baloxavir Marboxil Impurity 185 (CAS CATO-C4X-2108185)
- 3-(4-Chlorophenyl)-2-(morpholin-4-yl)quinoline (CAS 339013-36-4)
- 2-(But-3-en-1-yl)-5-methylcyclopentanone (CAS 38382-17-1)
- 4-[(4-Aminopiperidin-1-yl)methyl]-2-ethoxyphenol (CAS 946773-85-9)
- 4-Chloro-2-methyl-5-propoxypyridazin-3(2H)-one (CAS 102051-84-3)
- (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenyl-d5-carbamate (CAS 1331383-16-4)
- N-(tert-Butyl)-2-methylbenzamide (CAS 104847-07-6)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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