Rosuvastatin Impurity 131 CAS 1246665-85-9
| CAS No. | 1246665-85-9 |
| Molecular Formula | C22H24FN3O4S |
| Molecular Weight | 445.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Rosuvastatin Impurity 131 (CAS 1246665-85-9, C22H24FN3O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H24FN3O4S, Rosuvastatin Impurity 131 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 445.51 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Rosuvastatin Impurity 131 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24FN3O4S |
| Molecular Weight | 445.51 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 160 (CAS CATO-C4X-1169160)
- Rosuvastatin Impurity 162 (CAS 488798-40-9)
- Rosuvastatin Impurity 134 (CAS 1797419-58-9)
- Rosuvastatin Impurity 260 (CAS CATO-C4X-1169260)
- Rosuvastatin Impurity 48 (CAS CATO-C4X-116948)
- Rosuvastatin Impurity 180 (CAS CATO-C4X-1169180)
- Rosuvastatin Impurity 74 (CAS 615263-62-2)
- Rosuvastatin (2S,4S)-Lactone (CAS 1809092-87-2)
Recommended Standards
- Vonoprazan Impurity 238 (CAS 1831110-76-9)
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- N-Nitroso Ramipril (CAS CATO-C4X-174422)
- Quin C1 (CAS 786706-21-6)
- Aprepitant Impurity 72 (CAS 502537-07-7)
- Labetalol Impurity 23 (CAS 2724509-52-6)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
- 2-(Cyanomethyl)-5-nitrobenzimidazole (CAS 33137-87-0)
- Boldenone Benzoate (CAS 19041-66-8)
- N-benzyl-N-(3-(hydroxymethyl)oxetan-3-yl)-4-methylbenzenesulfonamide (CAS 2095219-05-7)
- Bis(4-(9H-carbazol-9-yl)phenyl)diphenylmethane (CAS 697312-24-6)
- 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (CAS 76330-71-7)
- 3-Hydroxybromazepam (CAS 13132-73-5)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
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