Aprepitant Impurity 72 CAS 502537-07-7
| CAS No. | 502537-07-7 |
| Molecular Formula | C13H12F3NO4 |
| Molecular Weight | 303.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Aprepitant Impurity 72.
Aprepitant Impurity 72 (CAS 502537-07-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12F3NO4 and a molecular weight of 303.23 g/mol.
Aprepitant Impurity 72 (C13H12F3NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprepitant Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12F3NO4 |
| Molecular Weight | 303.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 39 (CAS 176306-78-8)
- Aprepitant Impurity 32 (CAS 225920-05-8)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
- Aprepitant Impurity 45 (CAS 364-47-6)
- Aprepitant Impurity 76 (CAS CATO-C4X-114176)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 34 (CAS 30071-93-3)
Recommended Standards
- Tetraethyl (Aminomethylene)bis(phosphonate) (CAS 80474-99-3)
- Pomalidomide Impurity 11 (CAS 19171-18-7)
- N-(3,5-bis(trifluoromethyl)phenyl)hydrazinecarbothioamide (CAS 38901-31-4)
- Bumetanide Impurity 65 (CAS CATO-C4X-198665)
- Sitagliptin Tablets EP Impurity FP-B (CAS 2805078-75-3)
- Crisaborole impurity 109 (CAS CATO-C4X-2021109)
- SAR107375E Impurity 14 d8 (CAS CATO-C4X-229914)
- N-(3-(dimethoxymethyl)pyridin-4-yl)pivalamide (CAS 824429-52-9)
- 1,4-Bis(tris(4-bromophenyl)methyl)benzene (CAS 1449226-24-7)
- 1-(5-Fluoro-3-methylpyridin-2-yl)ethan-1-ol (CAS 2833706-85-5)
- 3-(2-Hydroxyethyl)-1,3-diazaspiro[4.5]decane-2,4-dione (CAS 882-67-7)
- 2,6-Dichloro-4-methoxypyridine (CAS 17228-75-0)
- Methyl 2-ethyl-6-methoxybenzoate (CAS 256664-96-7)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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